Deborah Santana, who in her 2005 memoir "Space Between the Stars" described her guitarist husband as being unfaithful, filed for divorce in Marin County Superior Court on Oct. 19, citing irreconcilable differences.
Carlos Santana's publicist, Michael Jensen, said the case is "a private matter and there is no comment."
The musician has said he knew he made mistakes in his marriage.
"I sincerely apologized to her and to my kids when I wasn't in my right mind and did something hurtful," Carlos Santana said after the memoir was published. "It has helped me become more humble and to try harder to be the man she wants me to be."
The Santanas have also been business partners. They created the Milagro Foundation, a nonprofit organization that supports underprivileged children.
Earlier this year, they announced plans to create three Mexican restaurants in the San Francisco Bay area named Maria, Maria after one of Carlos Santana's Grammy-winning songs.
The couple have three children, ages 17, 22 and 23.
Carlos Santana happy to be a hippie in Las Vegas
Jun 5, 2009 11:00 am PDT
Guitarist Carlos Santana has an answer for anyone who questions what a self-proclaimed hippie is doing playing a months-long residency in Las Vegas: He doesn't buy into anyone's illusions of who he is. Santana opened his new show ...
Santana's Wife Quits the Game of Love
Nov 2, 2007 12:00 pm PDT
There's at least one person who doesn't want to perform a duet with Carlos Santana. Deborah Santana, the revered guitarist's wife of 34 years, filed for divorce on Oct. 19, citing irreconcilable differences as the reason for t...
Santana plans to open themed restaurants
Feb 15, 2007 5:55 am PST
The newest addition to the roster of celebrity-inspired restaurants, Carlos Santana's Maria Maria, promises to deliver authentic Mexican cuisine in an atmosphere inspired by his music. The 59-year-old musician and his wife, Deborah, anno...
Carlos Santana Speaks Out Against Bush
Mar 20, 2006 5:17 pm PST
Carlos Santana quoted his old friend Jimi Hendrix in an anti-war message here Monday and said his philosophy is the antithesis of President George W. Bush's. "I have wisdom. I feel love. I live in the present and I try to present a dimen...