Kelis filed for divorce on Thursday in Los Angeles Superior Court, citing irreconcilable differences.
The couple are currently expecting their first baby together.
A spokesperson for Kelis informed Vibe: "I can confirm that she has filed for divorce. We request the media to respect her privacy during this very difficult time."
The couple met in 2002 at a party hosted by P. Diddy and married just over two years later. Kelis is currently seven months pregnant. She is asking for spousal and child support, according to TMZ.
For more on Kelis, check out her NME.com page.
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